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Covid: Trials to test combination of Oxford and Sputnik vaccines

UK and Russian scientists are teaming up to trial a combination of the Oxford-AstraZeneca and Sputnik V vaccines to see if protection against Covid-19 can be improved.
Mixing two similar vaccines could lead to a better immune response in people. The trials, to be held in Russia, will involve persons over the age of 18, although the number of people involved is unclear. While Oxford researchers are still collecting data on the effectiveness of its vaccine in older age groups, AstraZeneca is exploring combinations of different adenovirus vaccines, to find out whether mixing them leads to a better immune response and, therefore, greater protection.

Are two vaccines better than one?

Analysis box by James Gallagher, health and science correspondent

The hope is combining different vaccines will give either stronger or longer-lasting immunity to the virus.

There are reasons to think this might be beneficial for the Oxford and the Sputnik V jabs.

Both use harmless viruses to deliver the important part of the vaccine (a bit of the coronavirus’ genetic code) into the body.

The risk is the body becomes immune to the “viral postman” making the second or booster jab less effective.

This is one explanation for why Oxford had better results from giving someone a half dose followed by a full one, rather than two normal doses.

Other vaccine combinations are also planned in the hope that approaching the challenge from different angles will lead to better results.

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